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The main difference between androgenic and anabolic is that androgenic steroids generate male sex hormone-related activity whereas anabolic steroids increase both muscle mass and the bone mass. It is a matter for debate whether the bone changes in the male athlete are a consequence of anabolic steroid metabolism or because he also has anabolic steroid activity. In his study, Mölle et al. reported that testosterone supplementation had a positive effect on bone mineral density in both the anabolic and anabolic steroid subjects, but this effect was only significant in male athletes, although the effect was significant in male subjects without anabolic steroids. Furthermore, Mölle et al. reported that testosterone supplementation has little effect on bone density in female subjects . In addition, Leung et al. reported that anabolic steroid-treated subjects have smaller LBM in comparison to anabolic steroid controls whereas bone mineral density has been shown to be inversely correlated with bone mass in males aged 19 to 21 years . Thus, although the increase in bone mass in both the anabolic and anabolic steroid groups could be explained by testosterone, the increase in muscle mass may also be a consequence of the anabolic steroid metabolism. Furthermore, the anabolic steroid metabolism itself might be a consequence of the increase in bone mass which is likely the result of the anabolic steroids' muscle enhancing effects on the skeletal system. A significant increase in testosterone has been found in response to anabolic steroid administration but in only a very small number of male athletes (average of 50) . However, because of the absence of data regarding what the anabolic effect of a steroid is in relation to bone density, as well as the lack of any data regarding the effects in female athletes, the question remains open as to whether the increased testosterone in response to anabolic steroid administration is a consequence of the anabolic effects or the cause. For that purpose, the purpose of this study was to determine the effects of oral anabolic and androgenic steroids on the skeletal system of active male athletes. Materials and methods Participants A total of 10 male athletes (age 21 to 39 years; BMI 26.1 ± 3.3 kg/m2) participated in this study. Their height and weight were determined by DXA to a standard deviation of 0.75 ± 0.19 m ± 1.04 ± 0.11 kg. Body mass index (BMI; kg/m2) was calculated as follows : BMI-L = [BMI × (BW × Age)] 2 . The subjects were then randomly assigned to one of two groups: an a.m. group supplemented with testosterone gel (1 mg testosterone ester for 30 days Similar articles: